Maternal and Neonatal Outcomes in Pregnancies Complicated by Thrombocytopenia: A Global Meta-Analysis to Inform Clinical Prognosis and Obstetric Management
1Noman Ahmed, 2Nazia Suleman, 1Tahmoor Butt, 1Ali Daud, 3Erum Memon
1Agha Khan Hospital, Karachi
2Consultant Gynaecologist, Life Care Hospital, Maternity Home and Pain Clinic; Assistant Professor, Abu Ummara Medical and Dental College, Lahore, Pakistan
3OBGYN, Jinnah Medical and Dental college
Vol: 16/03
Received: April 25, 2026 Accepted: May 02, 2026 Published: July 20, 2026
ABSTRACT:
Background: Thrombocytopenia, characterized by a low platelet count, has been a subject of concern in the context of pregnancy outcomes. Several studies have investigated its impact on maternal and fetal health, but a comprehensive synthesis of existing literature is lacking. This meta-analysis aims to fill this gap by systematically reviewing and analyzing relevant studies to provide a clearer understanding of the association between thrombocytopenia and pregnancy outcomes.
Aim: The main goal of the current meta-analysis is to explore effect of thrombocytopenia on various pregnancy outcomes. Specifically, we aim to assess the risk of adverse maternal and fetal results related through thrombocytopenia throughout pregnancy.
Methods: A systematic literature review was conducted to identify eligible studies published up to cut-off date of this meta-analysis. Electronic databases were searched, and inclusion criteria were applied to select studies that reported on the relationship between thrombocytopenia and pregnancy outcomes. A quantitative synthesis of data was performed using appropriate statistical methods to calculate pooled effect estimates and assess heterogeneity across studies.
Results: The meta-analysis included a total of 25 studies meeting the inclusion criteria. Pooled analyses revealed a statistically significant association between thrombocytopenia throughout pregnancy and increased risks of adverse maternal outcomes and adverse fetal outcomes. Subgroup evaluates were conducted to explore potential sources of heterogeneity, including gestational age at diagnosis and severity of thrombocytopenia.
Conclusion: This comprehensive meta-analysis provides compelling indication of impact of thrombocytopenia on pregnancy outcomes. The findings underscore the importance of vigilant monitoring and timely interventions for pregnant individuals with thrombocytopenia to mitigate the associated risks. Further research is warranted to clarify primary mechanisms and refine clinical management strategies. Keywords: Thrombocytopenia, Pregnancy outcomes, Meta-analysis, Maternal health, Fetal health, Systematic review.