Emerging Narrative Biomarkers for the Early Identification and Risk Prediction of Type 2 Diabetes
1Dr. Rubia Javaid, 2Dr Asma Abbas, 3Hub e Ali, 4Babar Shahzad, 5Nazneen Tabbasum, 6Tabbasum Raja
1Al Shifa Eye Trust Hospital, Rawalpindi
2Service Hospital, Faisalabad
3UHS, Lahore
4PIMS, Islamabad
5Gangaram Hospital, Lahore
6Mayo Hospital, Lahore
7Service Hospital, Lahore
Vol: 15/03
Received: January 25, 2025 Accepted: March 02, 2025 Published: July 06, 2025
ABSTRACT
Background: Type 2 diabetes mellitus is a persistent metabolic condition highlighted by insulin resistance and β-cell dysfunction. Early detection of individuals at risk is critical to avert disease progression and complications. Traditional diagnostic and its methods, includes fasting blood glucose and HbA1c, may detect T2DM after remarkable metabolic disturbance has occurred.
Objective: This study aims to highlight and assess narrative biomarkers with potential for early detection of T2DM before the start of clinical symptoms or standardized diagnostic doorstep.
Methods: A cross-sectional study was held which involves 210 participants classify into norm glycemic, prediabetes, and newly identified T2DM groups. Blood samples were examined for traditional indicators and appearing biomarkers, which includes adiponectin, fetuin-A, fibroblast growth factor 21, and microRNAs.
Results: The narrative biomarkers manifest statistically remarkable differences across the three different groups. Adiponectin levels were in face and related to insulin resistance, while fetuin-A and FGF21 levels were elevated in prediabetes and diabetic participants. Specific circulating miRNAs also highlight distinct expression patterns, which relates with glucose dysregulation.
Conclusion: Narrative biomarkers includes adiponectin, fetuin-A, FGF21, and selected miRNAs gives promising potential for early detection of T2DM. Combining these into screening protocols could increase risk stratification and timely intercede strategies. Keywords: T2DM, MiRNAs, Standardized, fibroblast, adiponectin